Disclosure / Terms of use

By using this website or downloading these data, you and your collaborators (“investigators”) signify your assent to all of the following conditions:

1. These data are provided on an “AS-IS” and “AS-AVAILABLE” basis for scientific research and educational use only; without warranty of any type, expressed or implied (including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose); and without warranty as to the accuracy, completeness, currency or reliability of any content available through this website.
2. Use of this website and the content available on this website is at investigators’ sole risk. Investigators are responsible for taking all necessary precautions to ensure that any content you may obtain from the website is free of viruses.
3. MetaBrain results cannot be re-distributed for any purpose.
4. Investigators certify that they are in compliance with all applicable local, state, and federal laws and/or regulations and institutional policies regarding use of this data (e.g., including regarding human subjects and genetics research).
5. Investigators will cite the appropriate MetaBrain publication reference(s) when presenting or publishing on results based (directly or indirectly) on this data. (Please refer to references listed below.)
6. Investigators will never attempt to identify any participant.

How to cite

Please Cite: Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases by N. de Klein et al., Nature Genetics, 2023, doi: https://doi.org/10.1038/s41588-023-01300-6

Provided summary statistics - 2020-05-26 release

The 2020-05-26 release of summary statistics was provided with the submission of the preprint of our manuscript. These files can be found here.

Provided summary statistics - 2021-07-23 release

The summary statistics on this website include both significant and non-significant eQTL associations, and include summary statistics for each of the included datasets as well. Genome-wide summary statistics are not available for the trans-eQTL analysis however. The files presented below contain only the primary eQTLs. All genomic positions are on GRCh38. Each dataset has a '-TopEffects.txt.gz' file containing the top association per gene and permutation thresholds.

The format of these files is different from our previous release. All files have been sorted by position, bgzipped, and can be indexed using Tabix using the command tabix -f -s 2 -b 3 -e 3 -S 1 file.txt.gz, or downloaded below ([tbi] hyperlinks).

We have also added a set of column descriptions for the files below.

MD5 sums are here. You can use curl or wget for mass download. Total size of this repository is approximately 38Gb.

Note that while these summary statistics files also contain summary statistics for each included cohort/dataset, this excludes NABEC datasets, since this was prohibited by the data usage agreement. If you are curious about the changes we made after the pre-print, please have a look at the review reports published together with our manuscript.

Update 2023-07-13: Summary statistics for the trans-eQTL and ieQTL analysis are available as supplementary tables 17 and 8 (respectively) with our paper. You can download them from Nature Genetics. Please contact us if you have specific requests regarding summary statistics.

Basalganglia-EUR

2021-07-23-basalganglia-EUR-30PCs-chr1.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr2.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr3.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr4.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr5.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr6.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr7.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr8.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr9.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr10.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr11.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr12.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr13.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr14.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr15.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr16.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr17.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr18.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr19.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr20.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr21.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-chr22.txt.gz [tbi]
2021-07-23-basalganglia-EUR-30PCs-TopEffects.txt.gz

Cerebellum-EUR

2021-07-23-cerebellum-EUR-60PCs-chr1.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr2.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr3.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr4.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr5.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr6.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr7.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr8.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr9.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr10.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr11.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr12.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr13.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr14.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr15.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr16.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr17.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr18.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr19.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr20.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr21.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-chr22.txt.gz [tbi]
2021-07-23-cerebellum-EUR-60PCs-TopEffects.txt.gz

Cortex-AFR

2021-07-23-cortex-AFR-40PCs-chr1.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr2.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr3.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr4.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr5.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr6.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr7.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr8.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr9.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr10.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr11.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr12.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr13.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr14.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr15.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr16.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr17.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr18.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr19.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr20.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr21.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-chr22.txt.gz [tbi]
2021-07-23-cortex-AFR-40PCs-TopEffects.txt.gz

Cortex-EAS

2021-07-23-cortex-EAS-30PCs-chr1.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr2.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr3.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr4.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr5.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr6.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr7.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr8.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr9.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr10.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr11.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr12.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr13.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr14.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr15.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr16.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr17.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr18.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr19.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr20.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr21.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-chr22.txt.gz [tbi]
2021-07-23-cortex-EAS-30PCs-TopEffects.txt.gz

Cortex-EUR

2021-07-23-cortex-EUR-80PCs-chr1.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr2.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr3.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr4.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr5.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr6.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr7.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr8.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr9.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr10.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr11.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr12.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr13.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr14.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr15.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr16.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr17.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr18.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr19.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr20.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr21.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-chr22.txt.gz [tbi]
2021-07-23-cortex-EUR-80PCs-TopEffects.txt.gz

Hippocampus-EUR

2021-07-23-hippocampus-EUR-30PCs-chr1.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr2.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr3.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr4.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr5.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr6.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr7.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr8.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr9.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr10.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr11.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr12.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr13.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr14.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr15.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr16.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr17.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr18.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr19.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr20.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr21.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-chr22.txt.gz [tbi]
2021-07-23-hippocampus-EUR-30PCs-TopEffects.txt.gz

Spinalcord-EUR

2021-07-23-spinalcord-EUR-20PCs-chr1.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr2.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr3.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr4.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr5.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr6.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr7.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr8.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr9.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr10.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr11.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr12.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr13.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr14.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr15.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr16.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr17.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr18.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr19.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr20.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr21.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-chr22.txt.gz [tbi]
2021-07-23-spinalcord-EUR-20PCs-TopEffects.txt.gz

Contact

For questions, bug reports, or requests, please contact Ellen Tsai (ellen.tsai@biogen.com); Lude Franke (ludefranke@gmail.com); Niek de Klein (niekdeklein@gmail.com); or Harm-Jan Westra (h.j.westra@umcg.nl).