Disclosure / Terms of use

By using this website or downloading these data, you and your collaborators (“investigators”) signify your assent to all of the following conditions:
  1. These data are provided on an “AS-IS” and “AS-AVAILABLE” basis for scientific research and educational use only; without warranty of any type, expressed or implied (including but not limited to any warranty as to their performance, merchantability, or fitness for any particular purpose); and without warranty as to the accuracy, completeness, currency or reliability of any content available through this website.
  2. Use of this website and the content available on this website is at investigators’ sole risk. Investigators are responsible for taking all necessary precautions to ensure that any content you may obtain from the website is free of viruses.
  3. MetaBrain results cannot be re-distributed for any purpose.
  4. Investigators certify that they are in compliance with all applicable local, state, and federal laws and/or regulations and institutional policies regarding use of this data (e.g., including regarding human subjects and genetics research).
  5. Investigators will cite the appropriate MetaBrain publication reference(s) when presenting or publishing on results based (directly or indirectly) on this data. (Please refer to references listed below.)
  6. Investigators will never attempt to identify any participant.

How to cite

Please cite: Brain expression quantitative trait locus and network analysis reveals downstream effects and putative drivers for brain-related diseases by N. de Klein et al., bioRxiv, 2021. doi: https://doi.org/10.1101/2021.03.01.433439

Provided summary statistics

The summary statistics on this website include both significant and non-significant eQTL associations, and include summary statistics for each of the included datasets as well. Genome-wide summary statistics are not available for the trans-eQTL analysis however. The files presented below contain only the primary eQTLs. We also provide minor allele frequencies per SNP over all samples included in the meta-analysis, and SMR formatted results. All genomic positions are on GRCh38.

Basalganglia-EUR

2020-05-26-Basalganglia-EUR-1-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-2-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-3-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-4-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-5-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-6-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-7-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-8-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-9-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-10-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-11-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-12-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-13-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-14-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-15-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-16-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-17-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-18-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-19-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-20-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-21-biogenformat.txt.gz
2020-05-26-Basalganglia-EUR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Cerebellum-EUR

2020-05-26-Cerebellum-EUR-1-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-2-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-3-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-4-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-5-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-6-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-7-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-8-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-9-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-10-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-11-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-12-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-13-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-14-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-15-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-16-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-17-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-18-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-19-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-20-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-21-biogenformat.txt.gz
2020-05-26-Cerebellum-EUR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Cortex-EUR

2020-05-26-Cortex-EUR-1-biogenformat.txt.gz
2020-05-26-Cortex-EUR-2-biogenformat.txt.gz
2020-05-26-Cortex-EUR-3-biogenformat.txt.gz
2020-05-26-Cortex-EUR-4-biogenformat.txt.gz
2020-05-26-Cortex-EUR-5-biogenformat.txt.gz
2020-05-26-Cortex-EUR-6-biogenformat.txt.gz
2020-05-26-Cortex-EUR-7-biogenformat.txt.gz
2020-05-26-Cortex-EUR-8-biogenformat.txt.gz
2020-05-26-Cortex-EUR-9-biogenformat.txt.gz
2020-05-26-Cortex-EUR-10-biogenformat.txt.gz
2020-05-26-Cortex-EUR-11-biogenformat.txt.gz
2020-05-26-Cortex-EUR-12-biogenformat.txt.gz
2020-05-26-Cortex-EUR-13-biogenformat.txt.gz
2020-05-26-Cortex-EUR-14-biogenformat.txt.gz
2020-05-26-Cortex-EUR-15-biogenformat.txt.gz
2020-05-26-Cortex-EUR-16-biogenformat.txt.gz
2020-05-26-Cortex-EUR-17-biogenformat.txt.gz
2020-05-26-Cortex-EUR-18-biogenformat.txt.gz
2020-05-26-Cortex-EUR-19-biogenformat.txt.gz
2020-05-26-Cortex-EUR-20-biogenformat.txt.gz
2020-05-26-Cortex-EUR-21-biogenformat.txt.gz
2020-05-26-Cortex-EUR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Cortex-AFR

2020-05-26-Cortex-AFR-1-biogenformat.txt.gz
2020-05-26-Cortex-AFR-2-biogenformat.txt.gz
2020-05-26-Cortex-AFR-3-biogenformat.txt.gz
2020-05-26-Cortex-AFR-4-biogenformat.txt.gz
2020-05-26-Cortex-AFR-5-biogenformat.txt.gz
2020-05-26-Cortex-AFR-6-biogenformat.txt.gz
2020-05-26-Cortex-AFR-7-biogenformat.txt.gz
2020-05-26-Cortex-AFR-8-biogenformat.txt.gz
2020-05-26-Cortex-AFR-9-biogenformat.txt.gz
2020-05-26-Cortex-AFR-10-biogenformat.txt.gz
2020-05-26-Cortex-AFR-11-biogenformat.txt.gz
2020-05-26-Cortex-AFR-12-biogenformat.txt.gz
2020-05-26-Cortex-AFR-13-biogenformat.txt.gz
2020-05-26-Cortex-AFR-14-biogenformat.txt.gz
2020-05-26-Cortex-AFR-15-biogenformat.txt.gz
2020-05-26-Cortex-AFR-16-biogenformat.txt.gz
2020-05-26-Cortex-AFR-17-biogenformat.txt.gz
2020-05-26-Cortex-AFR-18-biogenformat.txt.gz
2020-05-26-Cortex-AFR-19-biogenformat.txt.gz
2020-05-26-Cortex-AFR-20-biogenformat.txt.gz
2020-05-26-Cortex-AFR-21-biogenformat.txt.gz
2020-05-26-Cortex-AFR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Cortex-EUR + Cortex-AFR, excluding ENA, no PCA correction

Trans-eQTL summary statistics
Trans-eQTL summary statistics (cross mapping genes removed)

Hippocampus-EUR

2020-05-26-Hippocampus-EUR-1-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-2-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-3-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-4-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-5-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-6-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-7-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-8-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-9-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-10-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-11-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-12-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-13-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-14-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-15-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-16-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-17-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-18-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-19-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-20-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-21-biogenformat.txt.gz
2020-05-26-Hippocampus-EUR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Spinalcord-EUR

2020-05-26-Spinalcord-EUR-1-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-2-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-3-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-4-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-5-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-6-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-7-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-8-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-9-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-10-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-11-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-12-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-13-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-14-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-15-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-16-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-17-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-18-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-19-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-20-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-21-biogenformat.txt.gz
2020-05-26-Spinalcord-EUR-22-biogenformat.txt.gz
Minor allele frequencies
SMR formatted files

Contact

For questions, bug reports, or requests, please contact Ellen Tsai (ellen.tsai@biogen.com); Lude Franke (ludefranke@gmail.com); Niek de Klein (niekdeklein@gmail.com); or Harm-Jan Westra (h.j.westra@umcg.nl).